Vitamin D3 Versus Methotrexate Versus Saline Injections for Plantar Warts

This clinical trial will compare vitamin D3 injections, methotrexate injections, and saline injections for plantar warts. Plantar warts are warts on the soles of the feet. The study will include 60 adults aged 18 to 50 years at Kafrelsheikh University Hospital, Egypt. The main questions are: * How well does each treatment clear plantar warts? * What side effects occur with each treatment? * Do the warts return after treatment? Participants will be assigned by chance to one of three groups, with 20 participants in each group: * Vitamin D3 injections into the warts. * Methotrexate injections into the warts. * Saline injections into the warts. Saline is a saltwater solution used as a placebo comparison. Participants will receive injections once a week until their

Inclusion Criteria: * Age 18 to 50 years. * Clinical diagnosis of plantar warts, with dermoscopic confirmation when the diagnosis is uncertain. * Willingness to participate and provide written informed consent. Exclusion Criteria: * Pregnancy or breastfeeding. * Use of systemic or topical treatments for warts within the month before enrollment. * Immunosuppressive diseases or current use of immunosuppressive drugs. * Hypercalcemia. * Renal disease or renal impairment. * Known hypersensitivity to any ingredient of the investigational products. * History of chronic disease, including hepatic disease or bleeding diathesis. * Local inflammation or infection.